Systemic bacterial invasion induced by sleep deprivation. Am J Physiol Regul Integr Comp Physiol 2000 Apr;278(4):R905-16
Date
04/06/2000Pubmed ID
10749778DOI
10.1152/ajpregu.2000.278.4.R905Scopus ID
2-s2.0-0033994880 (requires institutional sign-in at Scopus site) 219 CitationsAbstract
Profound sleep disruption in humans is generally believed to cause health impairments. Through comparative research, specific physical effects and underlying mechanisms altered by sleep deprivation are being elucidated. Studies of sleep-deprived animals previously have shown a progressive, chronic negative energy balance and gradual deterioration of health, which culminate in fatal bloodstream infection without an infectious focus. The present study investigated the conditions antecedent to advanced morbidity in sleep-deprived rats by determining the time course and distribution of live microorganisms in body tissues that are normally sterile. The tissues cultured for microbial growth included the blood, four major organs, six regional lymph nodes, the intestine, and the skin. The principal finding was early infection of the mesenteric lymph nodes by bacteria presumably translocated from the intestine and bacterial migration to and transient infection of extraintestinal sites. Presence of pathogenic microorganisms and their toxins in tissues constitutes a septic burden and chronic antigenic challenge for the host. Bacterial translocation and pathogenic sequelae provide mechanisms by which sleep deprivation appears to adversely affect health.
Author List
Everson CA, Toth LAAuthor
Carol A. Everson PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBacteria, Aerobic
Bacteria, Anaerobic
Bacterial Infections
Bacteriological Techniques
Body Weight
Chronic Disease
Eating
Gram-Negative Bacteria
Immunity
Intestines
Kidney
Liver
Lymph Nodes
Male
Neuroimmunomodulation
Rats
Rats, Sprague-Dawley
Skin
Sleep Deprivation
Spleen
Tail
