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Heat shock proteins in renal injury and recovery. Curr Opin Nephrol Hypertens 1998 Jul;7(4):407-12

Date

08/05/1998

Pubmed ID

9690040

DOI

10.1097/00041552-199807000-00010

Scopus ID

2-s2.0-0031873922   33 Citations

Abstract

Heat shock proteins, or stress proteins, are molecular chaperones responsible for protein processing and protection against cellular injury through the prevention of inappropriate peptide interactions. The distribution of individual stress proteins varies between regions of the kidney and within subcellular compartments both in normal and pathological conditions. Novel molecular chaperones have been identified in renal medullary cells which are unique, among mammalian cells, in routinely facing osmotic stress. Heat shock proteins can participate in renal injury as antigenic targets, but their primary role is beneficial, and these proteins may function by interacting with the cytoskeleton to protect against and assist recovery from cellular injury.

Author List

Van Why SK, Siegel NJ

Author

Scott K. Van Why MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Heat-Shock Proteins
Humans
Kidney
Renal Insufficiency