Heat shock proteins in renal injury and recovery. Curr Opin Nephrol Hypertens 1998 Jul;7(4):407-12
Date
08/05/1998Pubmed ID
9690040DOI
10.1097/00041552-199807000-00010Scopus ID
2-s2.0-0031873922 33 CitationsAbstract
Heat shock proteins, or stress proteins, are molecular chaperones responsible for protein processing and protection against cellular injury through the prevention of inappropriate peptide interactions. The distribution of individual stress proteins varies between regions of the kidney and within subcellular compartments both in normal and pathological conditions. Novel molecular chaperones have been identified in renal medullary cells which are unique, among mammalian cells, in routinely facing osmotic stress. Heat shock proteins can participate in renal injury as antigenic targets, but their primary role is beneficial, and these proteins may function by interacting with the cytoskeleton to protect against and assist recovery from cellular injury.
Author List
Van Why SK, Siegel NJAuthor
Scott K. Van Why MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsHeat-Shock Proteins
Humans
Kidney
Renal Insufficiency
