Consciousness transitions during epilepsy seizures through the lens of integrated information theory. Sci Rep 2024 Mar 04;14(1):5355
Date
03/05/2024Pubmed ID
38438478Pubmed Central ID
PMC10912751DOI
10.1038/s41598-024-56045-xScopus ID
2-s2.0-85186610819 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Consciousness is one of the most complex aspects of human experience. Studying the mechanisms involved in the transitions among different levels of consciousness remains as one of the greatest challenges in neuroscience. In this study we use a measure of integrated information (ΦAR) to evaluate dynamic changes during consciousness transitions. We applied the measure to intracranial electroencephalography (SEEG) recordings collected from 6 patients that suffer from refractory epilepsy, taking into account inter-ictal, pre-ictal and ictal periods. We analyzed the dynamical evolution of ΦAR in groups of electrode contacts outside the epileptogenic region and compared it with the Consciousness Seizure Scale (CCS). We show that changes on ΦAR are significantly correlated with changes in the reported states of consciousness.
Author List
Baglivo FH, Campora N, Mininni CJ, Kochen S, Lew SAuthor
Sean Lew MD Chief, Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsConsciousness
Epilepsy
Humans
Information Theory
Lens, Crystalline
Seizures
Unionidae
