New Approaches to Cardiovascular Disease and Its Management in Kidney Transplant Recipients. Transplantation 2022 Jun 01;106(6):1143-1158
Date
12/03/2021Pubmed ID
34856598DOI
10.1097/TP.0000000000003990Scopus ID
2-s2.0-85131314041 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Cardiovascular events, including ischemic heart disease, heart failure, and arrhythmia, are common complications after kidney transplantation and continue to be leading causes of graft loss. Kidney transplant recipients have both traditional and transplant-specific risk factors for cardiovascular disease. In the general population, modification of cardiovascular risk factors is the best strategy to reduce cardiovascular events; however, studies evaluating the impact of risk modification strategies on cardiovascular outcomes among kidney transplant recipients are limited. Furthermore, there is only minimal guidance on appropriate cardiovascular screening and monitoring in this unique patient population. This review focuses on the limited scientific evidence that addresses cardiovascular events in kidney transplant recipients. Additionally, we focus on clinical management of specific cardiovascular entities that are more prevalent among kidney transplant recipients (ie, pulmonary hypertension, valvular diseases, diastolic dysfunction) and the use of newer evolving drug classes for treatment of heart failure within this cohort of patients. We note that there are no consensus documents describing optimal diagnostic, monitoring, or management strategies to reduce cardiovascular events after kidney transplantation; however, we outline quality initiatives and research recommendations for the assessment and management of cardiovascular-specific risk factors that could improve outcomes.
Author List
Aziz F, Jorgenson M, Garg N, Parajuli S, Mohamed M, Raza F, Mandelbrot D, Djamali A, Dhingra RAuthor
Ravi Dhingra MBBS Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Cardiovascular DiseasesCohort Studies
Heart Failure
Humans
Kidney Transplantation
Risk Factors
Transplant Recipients
