Medical College of Wisconsin
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Diabetes and the risk of heart failure. Heart Fail Clin 2012 Jan;8(1):125-33

Date

11/24/2011

Pubmed ID

22108732

Pubmed Central ID

PMC3223386

DOI

10.1016/j.hfc.2011.08.008

Scopus ID

2-s2.0-82955233193 (requires institutional sign-in at Scopus site)   68 Citations

Abstract

Prevalence of diabetes and heart failure are increasing exponentially worldwide. Diabetes is well-known to increase the risk of heart failure independent of other traditional risk factors and ischemia. Current evidence indicates the presence of several biochemical and molecular changes associated with diabetes that lead to diastolic dysfunction or American Heart Association stage B heart failure. Some, if not all, changes may also predate the development of frank diabetes. In this review, the authors present some of the epidemiologic evidence and a brief description of major mechanistic pathways that favor the development of heart failure in prediabetic and diabetic states.

Author List

Dhingra R, Vasan RS

Author

Ravi Dhingra MBBS Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Diabetes Complications
Disease Progression
Heart Failure
Humans
Incidence
Risk Factors
United States