Faculty Collaboration Database

Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study. J Am Coll Cardiol 2005 Mar 01;45(5):685-9

Date

03/01/2005

Pubmed ID

15734611

DOI

10.1016/j.jacc.2004.11.046

Scopus ID

2-s2.0-14044257060 (requires institutional sign-in at Scopus site)   95 Citations

Abstract

OBJECTIVES: The goal of this study was to assess the relations of electrocardiographic QRS duration to left ventricular (LV) measurements in individuals without heart failure (HF) or prior myocardial infarction (MI).

BACKGROUND: Increased electrocardiographic QRS duration (>/=120 ms) is a marker of ventricular dyssynchrony.

METHODS: We evaluated the relations of maximal electrocardiographic QRS duration to echocardiographic LV dimensions in 4,534 Framingham Heart study participants (mean age 54 years, 57% women) without prior HF or MI. QRS duration was analyzed as a continuous variable and as categories (<100, 100 to 119, and >/=120 ms).

RESULTS: In linear regression models, LV mass, end-diastolic dimension, and septal and posterior wall thicknesses were positively related to log-QRS duration, whereas fractional shortening (FS) was inversely related (p < 0.001). There was a significant trend for increasing LV mass and dimensions, and decreasing FS across categories of QRS duration (p < 0.001). Left bundle branch block was associated with higher LV mass and lower FS compared with a normal QRS duration (p < 0.001).

CONCLUSIONS: In our community-based sample of individuals free of HF and MI, increasing electrocardiographic QRS duration was positively related to LV mass and dimensions, and inversely associated with LV FS. Additional investigations are warranted to elucidate the mechanisms underlying the observed associations.

Author List

Dhingra R, Ho Nam B, Benjamin EJ, Wang TJ, Larson MG, D'Agostino RB Sr, Levy D, Vasan RS

Author

Ravi Dhingra MBBS Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Bundle-Branch Block
Cardiac Volume
Cohort Studies
Echocardiography
Electrocardiography
Female
Humans
Hypertrophy, Left Ventricular
Linear Models
Long QT Syndrome
Male
Mathematical Computing
Middle Aged
Myocardial Contraction
Signal Processing, Computer-Assisted
Statistics as Topic
Ventricular Dysfunction, Left
Ventricular Remodeling