Faculty Collaboration Database

Spin-lock magnetic resonance imaging of muscle in patients with autosomal recessive limb girdle muscular dystrophy. J Neuroimaging 2000 Apr;10(2):73-7

Date

05/09/2000

Pubmed ID

10800259

DOI

10.1111/jon200010273

Scopus ID

2-s2.0-0033994894 (requires institutional sign-in at Scopus site)   6 Citations

Abstract

Spin-lock imaging is a new magnetic resonance imaging (MRI) technique used to reflect the microstructural integrity of muscle. The purpose of this study was to characterize spin-lock contrast (SLC) of calf muscles in limb girdle muscular dystrophy (LGMD). The calf muscles of 5 patients with LGMD and 10 healthy volunteers were imaged with an off-resonance magnetic resonance (MR) spin-lock suppression pulse. Spin-lock suppression ratios were calculated for anterior tibialis, posterior tibialis, soleus, and gastrocnemius muscles. Clinical assessments of muscle strength were compared to the spin-lock suppression ratios in the LGMD group. Strong SLC was observed in healthy muscles, with mean (+/- SD) suppression ratios ranging from 51.2% (+/- 3.6%) to 56.3% (+/- 1.3%). In diseased muscle, spin-lock signal suppression was reduced by 8%-70%, demonstrating an inverse correlation between symptom duration and suppression ratios. Spin-lock contrast in the patients with LGMD, as a reflection of tissue integrity, was best preserved in posterior tibialis, anterior tibialis, soleus, and gastrocnemius muscles in descending order. Clinical assessments did a poorer job of differentiating than SLC did and were in poor agreement with spin-lock suppression ratios. Spin-lock MRI can quantify microstructural changes in LGMD and appears to provide information not obtainable from clinical evaluations. This suggests that this noninvasive technique may be useful in evaluating the extent, progression, and response to therapy of LGMD.

Author List

Franczak MB, Ulmer JL, Jaradeh S, McDaniel JD, Mark LP, Prost RW

Authors

Malgorzata Franczak MD Professor in the Neurology department at Medical College of Wisconsin
Leighton Mark MD Emeritus Professor in the Radiology department at Medical College of Wisconsin
Robert Prost PhD Emeritus Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Case-Control Studies
Female
Humans
Leg
Magnetic Resonance Imaging
Male
Middle Aged
Muscle, Skeletal
Muscular Dystrophies