Cerebral and somatic near-infrared spectroscopy in normal newborns. J Pediatr Surg 2010 Jun;45(6):1306-10
Date
07/14/2010Pubmed ID
20620336DOI
10.1016/j.jpedsurg.2010.02.110Scopus ID
2-s2.0-77953837168 (requires institutional sign-in at Scopus site) 100 CitationsAbstract
PURPOSE: Near-infrared spectroscopy has been used increasingly in the pediatric population as a continuous, noninvasive indicator of trends in organ perfusion and oxygenation. We studied healthy newborn babies to establish normal values during rest and feeding.
METHODS: Forty-four term newborns were recruited. Near-infrared spectroscopy probes were placed on the forehead and over the right kidney to record cerebral (rSO(2)C) and renal-somatic (rSO(2)R) regional oxyhemoglobin saturation. Readings were collected continuously for 2 to 8 hours, spanning 1 to 3 feeding episodes.
RESULTS: Data were available on 26 patients, with an average age of 44 +/- 28 hours. The overall average rSO(2)C was 77.9% +/- 8.5%, rSO(2)R was 86.8% +/- 8.1%, and DeltarSO(2)RC (somatic-cerebral rSO(2) difference) was 8.9% +/- 9.4%. During feeding, rSO(2)C was minimally decreased (78.6% +/- 8.4% versus 78.0% +/- 9.0%, P = .023), rSO(2)R did not change (87.0% +/- 8.1% versus 87.3% +/- 8.0%, P = .31), and DeltarSO(2)RC was minimally increased (8.5% +/- 9.5% versus 9.2% +/- 9.1%, P = .014). Over the first 120 hours after birth, average rSO(2)C decreased (P < .01), and rSO(2)R remained relatively unchanged.
CONCLUSIONS: Clinical utility of near-infrared spectroscopy was partly limited by lack of normative data. These data demonstrate that regional oxygen extraction is greater across cerebral than across renal-somatic beds in normal newborns. Healthy newborns do not have clinically significant changes in organ oxygenation with feeding.
Author List
Bernal NP, Hoffman GM, Ghanayem NS, Arca MJAuthor
George M. Hoffman MD Chief, Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BrainCerebrovascular Circulation
Female
Humans
Infant, Newborn
Kidney
Male
Oxygen Consumption
Reference Values
Renal Circulation
Reproducibility of Results
Spectroscopy, Near-Infrared