Potential Interactions between miRNAs and Hypoxia: A New Layer in Cancer Hypoxia. Anticancer Agents Med Chem 2021;21(17):2315-2326
Date
02/11/2021Pubmed ID
33563185DOI
10.2174/1871520621666210201100326Scopus ID
2-s2.0-85107486808 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Hypoxia pathway and aberrant miRNA expression profile play crucial roles in the development of various cancers. Recent studies have emphasized that there are many collaborations in this cases because both of them are involved in cancer cell processes, including differentiation, metastasis, and cell proliferation and signaling pathways. Further studies have elucidated that miRNAs affect the hypoxia route, and more interestingly, the hypoxia pathway also affects miRNAs expression profile. The literature review summarizes the fundamental roles of hypoxia-related miRNAs in different cancers. The mutual interactions between miRNAs and hypoxia are a new layer of complexity in cancer hypoxia, which might be helpful in controlling cancer progression. It is also possible that the hypoxia pathway is initiated by miRNAs. In contrast, the hypoxia pathway regulates the expression of a large group of miRNAs. In this review for the first time, we discussed the significant interactions between hypoxia and miRNAs in order to determine new perspectives for new therapeutic aims in the field of cancer.
Author List
Tapeh BE, Alivand MR, Solalii SAuthor
Mohammadreza Alivand DPhil Postdoctoral Researcher 1 in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
HumansMicroRNAs
Tumor Hypoxia
