Faculty Collaboration Database

The effect of royal jelly and tocotrienol-rich fraction along with calorie restriction on hypothalamic endoplasmic reticulum stress and adipose tissue inflammation in diet-induced obese rats. BMC Res Notes 2020 Aug 31;13(1):409

Date

09/02/2020

Pubmed ID

32867829

Pubmed Central ID

PMC7460780

DOI

10.1186/s13104-020-05258-0

Scopus ID

2-s2.0-85090103621 (requires institutional sign-in at Scopus site)   8 Citations

Abstract

OBJECTIVES: Endoplasmic reticulum (ER) stress causes adipose tissue dysfunction and chronic inflammation in obesity. Royal jelly (RJ) and tocotrienol-rich fraction (TRF) are reported to ameliorate inflammation. However, the improving effects of RJ and TRF on inflammation from ER stress modulating view have not been assessed so far. Hence, we investigated the effect of RJ and TRF on ER stress and some adipose tissue-derived inflammatory markers in the high-fat diet (HFD)-induced obesity. Wistar obese rats randomly allocated into 5 groups: HFD, calorie restriction diet (CRD), RJ + CRD, TRF + CRD, RJ + TRF + CRD. After 8-week intervention, adipose tissues and hypothalamus were dissected and serum was collected.

RESULTS: RJ reduced glucose-regulated protein-78 (GRP78) expression as ER stress indicator in WAT and hypothalamus compared to CRD. Besides, RJ diminished the expression of inflammatory markers in white adipose tissue (WAT) and also decreased the serum concentration of them. TRF reduced inflammatory markers in the serum without remarkable effects on ER stress. Overall, RJ has protective effect against adipose tissue dysfunction and inflammation then suggested as a therapeutic approach to reduce some obesity-related complications. The impact of TRF in this regard is lower than RJ and limited to systemic inflammation improvement without remarkable changes in adipose tissue inflammation.

Author List

Irandoost P, Mesri Alamdari N, Saidpour A, Shidfar F, Farsi F, Asghari Jafarabadi M, Alivand MR, Vafa M

Author

Mohammadreza Alivand DPhil Postdoctoral Researcher 1 in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adipose Tissue
Animals
Caloric Restriction
Diet, High-Fat
Endoplasmic Reticulum Stress
Fatty Acids
Hypothalamus
Inflammation
Obesity
Rats
Rats, Wistar
Tocotrienols