Principles of tissue engineering applied to programmable osteogenesis. J Biomed Mater Res 1998;43(4):380-98
Date
12/17/1998Pubmed ID
9855197DOI
10.1002/(sici)1097-4636(199824)43:4<380::aid-jbm6>3.0.co;2-dScopus ID
2-s2.0-0032400866 (requires institutional sign-in at Scopus site) 142 CitationsAbstract
This article presents a strategy for design, engineering, and fabrication of a bioresorbable, manufactured bone graft substitute (BGS) device. The approach is based on established precepts of osteogenesis, molecular biology of hyaluronic acid and osteoinductive proteins, and theoretical preformance criteria for such a device collated from the literature of 1991 to 1996. Application of this design and engineering strategy results in a composite device consisting of a D,D-L,L-polylactic acid macrostructure optimized to the architecture of cancellous bone, a microstructure composed of a filamentous velour of hyaluronan and a recombinant human bone morphogenetic protein 2 (rhBMP-2). The performance of this construct was tested in vivo in the dog, intertransverse process, spinal fusion model and in a critical sized defect of the rabbit radius. Data from these studies are used to illustrate principle points of the design and engineering concept.
Author List
Brekke JH, Toth JMAuthor
Jeffrey M. Toth PhD Associate Dean for Research in the School of Dentistry department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AnimalsBiocompatible Materials
Bone Substitutes
Bone and Bones
Cells, Cultured
Chemical Phenomena
Chemistry, Physical
Engineering
Humans
Hyaluronic Acid
Lactic Acid
Materials Testing
Microscopy, Electron, Scanning
Osteoblasts
Osteogenesis
Phenotype
Polyesters
Polymers
Rabbits
Spinal Fusion
Surface Properties
