Faculty Collaboration Database

Nanotechnology in diagnosis and treatment of coronary artery disease. Nanomedicine (Lond) 2016;11(5):513-30

Date

02/26/2016

Pubmed ID

26906471

Pubmed Central ID

PMC4794112

DOI

10.2217/nnm.16.3

Scopus ID

2-s2.0-84962616693 (requires institutional sign-in at Scopus site)   76 Citations

Abstract

Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis. Nanotechnology can increase the efficiency of drugs, improve local and systematic delivery to atherosclerotic plaques and reduce the inflammatory or angiogenic response after intravascular intervention. Nanocarriers have potential for delivery of imaging and diagnostic agents to precisely targeted destinations. This review paper will cover the current applications and future outlook of nanotechnology, as well as the main diagnostic methods, in the treatment of CAD.

Author List

Karimi M, Zare H, Bakhshian Nik A, Yazdani N, Hamrang M, Mohamed E, Sahandi Zangabad P, Moosavi Basri SM, Bakhtiari L, Hamblin MR

Author

Amirala Bakhshiannik PhD, MS Postdoctoral Researcher 4 in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Coronary Artery Disease
Drug Carriers
Humans
Nanoparticles
Nanotechnology
Plaque, Atherosclerotic