Challenges in the postsurgical recovery of cushing syndrome: glucocorticoid withdrawal syndrome. Front Endocrinol (Lausanne) 2024;15:1353543
Date
04/29/2024Pubmed ID
38681763Pubmed Central ID
PMC11045978DOI
10.3389/fendo.2024.1353543Scopus ID
2-s2.0-85191470213 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
Glucocorticoid withdrawal syndrome is a challenging clinical phenomenon that can complicate the postsurgical recovery of Cushing syndrome. It is characterized by physical tolerance and dependence to supraphysiologic glucocorticoid exposure during active Cushing syndrome followed by the abrupt decline in cortisol levels after surgical treatment. The symptoms of glucocorticoid withdrawal often overlap with those of postoperative adrenal insufficiency and can be difficult for patients to cope with and for clinicians to treat. This mini review will discuss the clinical characteristics, pathophysiology, and management of glucocorticoid withdrawal syndrome while highlighting recent data in the field.
Author List
Zhang CD, Ioachimescu AGAuthors
Adriana G. Ioachimescu PhD, MD Professor in the Medicine department at Medical College of WisconsinCatherine Zhang MD Assistant Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Adrenal InsufficiencyCushing Syndrome
Glucocorticoids
Humans
Postoperative Complications
Substance Withdrawal Syndrome
