Divergent Cellular Expression Patterns of PD-L1 and PD-L2 Proteins in Breast Cancer. J Pers Med 2024 Apr 29;14(5)
Date
05/25/2024Pubmed ID
38793060Pubmed Central ID
PMC11121947DOI
10.3390/jpm14050478Scopus ID
2-s2.0-85194400127 (requires institutional sign-in at Scopus site) 1 CitationAbstract
PD-L1 immunohistochemistry (IHC) has become an established method for predicting cancer response to targeted anti-PD1 immunotherapies, including breast cancer (BC). The alternative PD-1 ligand, PD-L2, remains understudied but may be a complementary predictive marker. Prospective analysis of 32 breast cancers revealed divergent expression patterns of PD-L1 and PD-L2. PD-L1-positivity was higher in immune cells than in cancer cells (median = 5.0% vs. 0.0%; p = 0.001), whereas PD-L2-positivity was higher in cancer cells than immune cells (median = 30% vs. 5.0%; p = 0.001). Percent positivity of PD-L1 and PD-L2 were not correlated, neither in cancer cells nor immune cells. Based on a cut-point of ≥1% positivity, ER+ tumors (n = 23) were frequently PD-L2-positive (73.9%), whereas only 40.9% were PD-L1-positive. These data suggest differential control of cellular PD-L1 and PD-L2 expression in BC and a potential role for PD-L2 IHC as a complementary marker to PD-L1 to improve selection of aggressive ER+ BC that may benefit from anti-PD-1 therapy.
Author List
Jorns JM, Sun Y, Kamaraju S, Cheng YC, Kong A, Yen T, Patten CR, Cortina CS, Chitambar CR, Rui H, Chaudhary LNAuthors
Lubna N. Chaudhary MD Associate Professor in the Medicine department at Medical College of WisconsinChandler S. Cortina MD Associate Professor in the Surgery department at Medical College of Wisconsin
Julie M. Jorns MD Professor in the Pathology and Laboratory Medicine department at Medical College of Wisconsin
Sailaja Kamaraju MBBS, MS Professor in the Medicine department at Medical College of Wisconsin
Amanda L. Kong MS, MD Professor in the Surgery department at Medical College of Wisconsin
Caitlin R. Patten MD Associate Professor in the Surgery department at Medical College of Wisconsin
Tina W F Yen BA, MS, MD Professor in the Surgery department at Medical College of Wisconsin
