Comparison of intraocular to plasma HIV-1 viral burden in patients with cytomegalovirus retinitis. Am J Ophthalmol 1999 Feb;127(2):221-3
Date
02/25/1999Pubmed ID
10030574DOI
10.1016/s0002-9394(98)00345-6Scopus ID
2-s2.0-0033006903 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
PURPOSE: To determine the relationship between plasma and intraocular human immunodeficiency virus-1 (HIV-1) viral loads in 12 consecutive patients undergoing ganciclovir implant surgery for cytomegalovirus (CMV) retinitis.
METHODS: Aqueous and vitreous specimens were assayed for HIV-1 viral load by polymerase chain reaction analysis (Roche Amplicor HIV Monitor; Roche Diagnostics Systems, Inc, Branchburg, New Jersey).
RESULTS: It was possible to quantitatively assay HIV-1 burden in intraocular fluids using polymerase chain reaction analysis. In general, patients with plasma viral loads less than 250,000 copies/ml had undetectable (<200 copies/ml) HIV-1 in their aqueous and vitreous.
CONCLUSIONS: It is likely that intraocular viral levels have several determinants in addition to plasma viral loads, with which they only partially correlate.
Author List
Ciulla TA, Schnizlein-Bick CT, Danis RP, Frank MO, Wheat LJAuthor
Michael O. Frank MD Chief, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AIDS-Related Opportunistic InfectionsAqueous Humor
Cytomegalovirus Retinitis
Drug Implants
Ganciclovir
HIV-1
Humans
Polymerase Chain Reaction
RNA, Viral
Viral Load
Vitreous Body
