Histology of the urethral plate: implications for hypospadias repair. J Urol 2000 Sep;164(3 Pt 2):988-9; discussion 989-90
Date
08/25/2000Pubmed ID
10958724DOI
10.1097/00005392-200009020-00017Scopus ID
2-s2.0-0033870746 (requires institutional sign-in at Scopus site) 97 CitationsAbstract
PURPOSE: We define the histology of the urethral plate in boys with hypospadias.
MATERIALS AND METHODS: Subepithelial biopsies of the urethral plate were obtained in 17 boys, including 13 with distal and 4 with penoscrotal hypospadias. Ventral penile curvature was noted in 5 cases. Specimens were evaluated by 7 light microscopy after hematoxylin and eosin staining.
RESULTS: All biopsies demonstrated well vascularized connective tissue comprised of smooth muscle and collagen. There was no evidence of fibrous bands or dysplastic tissue.
CONCLUSIONS: The urethral plate consists of epithelium overlying connective tissue. We found no histological evidence of fibrous cords historically considered responsible for chordee.
Author List
Snodgrass W, Patterson K, Plaire JC, Grady R, Mitchell MEAuthor
Michael Ernst Mitchell MD Emeritus Professor in the Urology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ChildHumans
Hypospadias
Male
Urethra
