Histone oxidation as a new mechanism of metabolic control over gene expression. Trends Genet 2024 Sep;40(9):739-746
Date
06/24/2024Pubmed ID
38910033Pubmed Central ID
PMC11387142DOI
10.1016/j.tig.2024.05.012Scopus ID
2-s2.0-85196478706 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
The emergence of aerobic respiration created unprecedented bioenergetic advantages, while imposing the need to protect critical genetic information from reactive byproducts of oxidative metabolism (i.e., reactive oxygen species, ROS). The evolution of histone proteins fulfilled the need to shield DNA from these potentially damaging toxins, while providing the means to compact and structure massive eukaryotic genomes. To date, several metabolism-linked histone post-translational modifications (PTMs) have been shown to regulate chromatin structure and gene expression. However, whether and how PTMs enacted by metabolically produced ROS regulate adaptive chromatin remodeling remain relatively unexplored. Here, we review novel mechanistic insights into the interactions of ROS with histones and their consequences for the control of gene expression regulation, cellular plasticity, and behavior.
Author List
Gantner BN, Palma FR, Kayzuka C, Lacchini R, Foltz DR, Backman V, Kelleher N, Shilatifard A, Bonini MGAuthor
Benjamin N. Gantner PhD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsChromatin
Chromatin Assembly and Disassembly
Gene Expression Regulation
Histones
Humans
Oxidation-Reduction
Protein Processing, Post-Translational
Reactive Oxygen Species
