[Effects of rapamycin on amyloid β-protein induced impairments of working memory and synaptic plasticity in rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2016 Jan;32(1):18-21
Date
06/04/2016Pubmed ID
27255034Scopus ID
2-s2.0-84983616668 (requires institutional sign-in at Scopus site)Abstract
OBJECTIVE: The present study investigated the effects of rapamycin on Aβ1-42-induced deficits in working memory and synaptic plasticity.
METHODS: After bilateral hippocampal injection of Aβ1-42 and rapamycinin rats, spontaneous alternation in Y-maze and in vivo hippocampal long-term potentiation (LTP) of rats were recorded. All data were analized by two-way repeated measures analysis of variance (ANOVA).
RESULTS: (Hippocampal injection of Aβ1-42 alone impaired working memory of rats; (2) Rapamycin did not affect working memory of rats, but alleviated Aβ1-42-induced working memory deficits, compared with Aβ1-42 alone group; (Aβ1-42 remarkably suppressed in vivo hippocampal LTP of fEPSPs in the CA1 region; (4) Pretreatment with rapamycin prevented Aβ1-42-induced suppression of LTP.
CONCLUSION: These data indicates that rapamycin could protect against Aβ1-42-induced impairments in working memory and synaptic plasticity in rats.
Author List
Hao M, Tong JQ, Zhang J, Wu MN, Qi JSAuthor
Jiaqing Tong PhD Postdoctoral Researcher 3 in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Amyloid beta-PeptidesAnimals
Hippocampus
Long-Term Potentiation
Maze Learning
Memory, Short-Term
Neuronal Plasticity
Peptide Fragments
Rats
Sirolimus
