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Nontypeable Haemophilus influenzae challenge during gammaherpesvirus infection enhances viral reactivation and latency. Virology 2024 Sep;597:110153

Date

06/29/2024

Pubmed ID

38941745

Pubmed Central ID

PMC11257779

DOI

10.1016/j.virol.2024.110153

Scopus ID

2-s2.0-85196778582 (requires institutional sign-in at Scopus site)

Abstract

Gammaherpesviruses are ubiquitous, lifelong pathogens associated with multiple cancers that infect over 95% of the adult population. Increases in viral reactivation, due to stress and other unknown factors impacting the immune response, frequently precedes lymphomagenesis. One potential stressor that could promote viral reactivation and increase viral latency would be the myriad of infections from bacterial and viral pathogens that we experience throughout our lives. Using murine gammaherpesvirus 68 (MHV68), a mouse model of gammaherpesvirus infection, we examined the impact of bacterial challenge on gammaherpesvirus infection. We challenged MHV68 infected mice during the establishment of latency with nontypeable Haemophilus influenzae (NTHi) to determine the impact of bacterial infection on viral reactivation and latency. Mice infected with MHV68 and then challenged with NTHi, saw increases in viral reactivation and viral latency. These data support the hypothesis that bacterial challenge can promote gammaherpesvirus reactivation and latency establishment, with possible consequences for viral lymphomagenesis.

Author List

Huss NP, Majeed ST, Wills BM, Tarakanova VL, Brockman KL, Jondle CN

Authors

Kenneth Brockman PhD Assistant Professor in the Microbiology and Immunology department at Medical College of Wisconsin
Vera Tarakanova PhD Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Disease Models, Animal
Female
Gammaherpesvirinae
Haemophilus Infections
Haemophilus influenzae
Herpesviridae Infections
Mice
Mice, Inbred C57BL
Rhadinovirus
Virus Activation
Virus Latency