Faculty Collaboration Database

Human papillomavirus infection in "young" versus "old" patients with squamous cell carcinoma of the head and neck. Head Neck 2000 Oct;22(7):649-57

Date

09/26/2000

Pubmed ID

11002318

DOI

10.1002/1097-0347(200010)22:7<649::aid-hed2>3.0.co;2-b

Scopus ID

2-s2.0-0034295022 (requires institutional sign-in at Scopus site)   48 Citations

Abstract

BACKGROUND: Human papillomavirus (HPV) represents a potential risk factor for squamous cell cancer of the head and neck (SCCHN). We evaluated the prevalence of HPV DNA in patients with SCCHN diagnosed at the University of Michigan from 1994-1996.

METHODS: Patients were stratified by age at diagnosis as "young" (<50 years; median, 39) or "old" (>50 years; median, 66). Fourteen "young" and 14 "old" were matched for tumor site, and 4 additional "old" patients were included. Specimens were analyzed by polymerase chain reaction for HPV DNA using 2 sets of consensus primers. HPV sequences were confirmed by Southern blot hybridization and typed with type-specific probes.

RESULTS: Overall, 15 of 32 (46.9%) samples contained HPV sequences. HPV 16 was detected in 9 of 15 (60%), HPV-18 in 1 of 15 (6.6%), and 5 of 15 (33.3%) remained untyped by multiple methods. When stratified, 7 of 14 (50%) "young" were HPV-positive compared with 8 of 18 (44.4%) "old" (p =.76). Survival in patients with HPV-positive SCCHN was significantly longer than that for HPV-negative patients.

CONCLUSIONS: The incidence of HPV in "young" versus "old" is not significantly different, suggesting similar roles for both groups. Patients with HPV-positive tumors may have a survival advantage relative to patients with HPV-negative tumors.

Author List

Sisk EA, Bradford CR, Jacob A, Yian CH, Staton KM, Tang G, Harris MO, Carey TE, Lancaster WD, Gregoire L

Author

Elizabeth A. Sisk MD Adjunct Assistant Professor in the Otolaryngology and Communication Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Blotting, Southern
Carcinoma, Squamous Cell
DNA, Neoplasm
DNA, Viral
Head and Neck Neoplasms
Humans
Middle Aged
Papillomaviridae
Papillomavirus Infections
Polymerase Chain Reaction
Retrospective Studies
Survival Rate
Tumor Virus Infections