Clinical Implications of COVID-19-Related Endothelial Dysfunction. JACC Adv 2024 Aug;3(8):101070
Date
07/26/2024Pubmed ID
39055276Pubmed Central ID
PMC11269277DOI
10.1016/j.jacadv.2024.101070Scopus ID
2-s2.0-85197318304 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
Endothelial dysfunction represents a measurable and early manifestation of vascular disease. Emerging evidence suggests cardiovascular risk remains elevated after COVID-19 infection for at least 12 months, regardless of cardiovascular disease status prior to infection. We review the relationship between the severity of endothelial dysfunction and the severity of acute COVID-19 illness, the degree of impairment following recovery in both those with and without postacute sequalae SARS-CoV-2 infection, and current therapeutic efforts targeting endothelial function in patients following COVID-19 infection. We identify gaps in the literature to highlight specific areas where clinical research efforts hold promise for progress in understanding the connections between endothelial function, COVID-19, and clinical outcomes that will lead to beneficial therapeutics.
Author List
Aljadah M, Khan N, Beyer AM, Chen Y, Blanker A, Widlansky MEAuthors
Michael M. Aljadah MD Instructor in the Medicine department at Medical College of WisconsinAndreas M. Beyer PhD Professor in the Medicine department at Medical College of Wisconsin
Michael E. Widlansky MD Center Director, Interim Chief, Professor in the Medicine department at Medical College of Wisconsin
