Magnetic Cell Targeting for Cardiovascular Tissue Engineering. Tissue Eng Part B Rev 2025 Jun;31(3):234-247
Date
07/30/2024Pubmed ID
39078330Pubmed Central ID
PMC12223378DOI
10.1089/ten.TEB.2024.0103Scopus ID
2-s2.0-85201691441 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
There is a critical need for novel approaches to translate cell therapy and regenerative medicine to clinical practice. Magnetic cell targeting with site specificity has started to open avenues in these fields as a potential therapeutic platform. Magnetic targeting is gaining popularity in the field of biomedicine due to its ability to concentrate and retain at a target site while minimizing deleterious effects at off-target sites. It is regarded as a relatively straightforward and safe approach for a wide range of therapeutic applications. This review discusses the latest advancements and approaches in magnetic cell targeting using endocytosed and surface-bound magnetic nanoparticles as well as in vivo tracking using magnetic resonance imaging (MRI). The most common form of magnetic nanoparticles is superparamagnetic iron oxide nanoparticles (SPION). The biodegradable and biocompatible properties of these magnetically responsive particles and capacity for rapid endocytosis into cells make them a breakthrough in targeted therapy. This review further discusses specific applications of magnetic targeting approaches in cardiovascular tissue engineering including myocardial regeneration, therapeutic angiogenesis, and endothelialization of implantable cardiovascular devices.
Author List
Shradhanjali A, Wolfe JT, Tefft BJAuthor
Brandon J. Tefft PhD Associate Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCardiovascular System
Humans
Magnetite Nanoparticles
Tissue Engineering
