Primate trabeculectomies with 5-fluorouracil collagen implants. Am J Ophthalmol 1990 Jun 15;109(6):721-5
Date
06/15/1990Pubmed ID
2189316DOI
10.1016/s0002-9394(14)72443-2Scopus ID
2-s2.0-0025376335 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
Bilateral trabeculectomies were performed on four normal cynomolgus monkeys. Highly purified bovine skin collagen implants with either 1 mg of 5-fluorouracil or physiologic saline (one each per monkey by randomized, masked assignment) were sutured under the scleral flaps. The randomization code was not broken until all clinical and histopathologic observations had been completed. Six weeks postoperatively, the 5-fluorouracil-treated eyes had more deeply open internal trabeculectomy ostia than the control eyes; however, the intraocular pressures were indistinguishable, the filtering blebs were only minimally different, and half of each group had trace or mild anterior subcapsular lenticular changes. Histologically, a multinucleated foreign body giant cell reaction was evident in all of the collagen implants, but the 5-fluorouracil-treated eyes had less vigorous or delayed reactions compared to the control eyes. The collagen implant appears to be a poor drug delivery system in this model of glaucoma filtering surgery, because it incites a granulomatous inflammatory reaction.
Author List
Hasty B, Heuer DK, Minckler DSAuthor
Dale Heuer MD Emeritus Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnterior Chamber
Biological Dressings
Double-Blind Method
Drug Implants
Fibroblasts
Fluorouracil
Foreign-Body Reaction
Giant Cells, Foreign-Body
Intraocular Pressure
Macaca fascicularis
Random Allocation
Surgical Flaps
Trabeculectomy
Wound Healing
