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Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol 2011 Jan;33(1):67-87

Date

04/29/2010

Pubmed ID

20424843

DOI

10.1007/s00281-010-0204-1

Scopus ID

2-s2.0-79251621206 (requires institutional sign-in at Scopus site)   154 Citations

Abstract

For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type 1 diabetes (T1D). However, while sharing many similarities, it is becoming increasingly appreciated that there are also some differences in the immunopathogenic basis of T1D development between humans and NOD mice. This review will focus on aspects of T1D development in NOD mice that are similar and different from that in humans.

Author List

Driver JP, Serreze DV, Chen YG

Author

Yi-Guang Chen PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Antigen-Presenting Cells
Diabetes Mellitus, Type 1
Disease Models, Animal
Humans
Mice
Mice, Inbred NOD
T-Lymphocytes