Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Robust indices of Hardy-Weinberg disequilibrium for QTL fine mapping. Hum Hered 2003;56(4):160-5

Date

03/20/2004

Pubmed ID

15031618

DOI

10.1159/000076391

Scopus ID

2-s2.0-1642635110   4 Citations

Abstract

Hardy-Weinberg disequilibrium (HWD) measures have been proposed using dense markers to fine map a quantitative trait locus (QTL) to regions < approximately 1 cM. Earlier HWD measures may introduce bias in the fine mapping because they are dependent on marker allele frequencies across loci. Hence, HWD indices that do not depend on marker allele frequencies are desired for fine mapping. Based on our earlier work, here we present four new HWD indices that do not depend on marker allele frequencies. Two are for use when marker allele frequencies in a study population are known, and two are for use when marker allele frequencies in a study population are not known and are only known in the extreme samples. The new measures are a function of the genetic distance between the marker locus and a QTL. Through simulations, we investigated and compared the fine mapping performance of the new HWD measures with that of the earlier ones. Our results show that when marker allele frequencies vary across loci, the new measures presented here are more robust and powerful.

Author List

Deng HW, Li YM, Li MX, Liu PY

Author

Pengyuan Liu PhD Adjunct Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Chromosome Mapping
Computer Simulation
Genetic Markers
Humans
Linkage Disequilibrium
Quantitative Trait Loci
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d