The effect of cyst(e)ine on the auto-oxidation of homocysteine. Free Radic Biol Med 1999 Jul;27(1-2):28-33
Date
08/12/1999Pubmed ID
10443916DOI
10.1016/s0891-5849(99)00029-5Scopus ID
2-s2.0-0032797368 (requires institutional sign-in at Scopus site) 112 CitationsAbstract
This study examines the effect of cysteine on the auto-oxidation of homocysteine, a process that has been implicated in the pathologic mechanism of hyperhomocystinemia with respect to arteriosclerosis and vascular disease. It is shown that homocysteine autoxidizes at a much slower rate than cysteine, but that low concentrations of cysteine or cystine dramatically accelerate homocysteine oxidation and increase the rate of homocysteine-dependent oxygen consumption. It is proposed that the major role of homocysteine is to reduce cystine to cysteine, and that cysteine autoxidation is the mechanism by which thiol-dependent oxidative stress occurs.
Author List
Hogg NAuthor
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CysteineCystine
Glutathione
Homocysteine
Oxidation-Reduction
