Role of local angiotensin II signaling in bladder function. Am J Physiol Renal Physiol 2024 Nov 01;327(5):F726-F738
Date
09/12/2024Pubmed ID
39265080Pubmed Central ID
PMC11563647DOI
10.1152/ajprenal.00204.2024Scopus ID
2-s2.0-85207596708 (requires institutional sign-in at Scopus site)Abstract
Angiotensin II signaling plays a crucial role in many different diseases. Although it has been known for several decades that local angiotensin II signaling molecules are present in the bladder, the understanding of their functions there is still limited, especially compared with other organ systems such as cardiovascular and respiratory systems. This article reviews current literature regarding local angiotensin II signaling in the urinary bladder. By reviewing several decades of literature, the field has provided strong evidence to support the presence of local angiotensin II signaling in the bladder, including the expression of angiotensin type 1 receptor and angiotensin type 2 receptor in both human and animal tissues. In addition, evidence suggests a functional role of angiotensin type 1 receptor in mediating bladder contractions. In bladder disease models, angiotensin II signaling can be upregulated, and angiotensin type 1 receptor activity is associated with increases in inflammation, fibrosis, and oxidative stress. We also address the gaps in knowledge that remain in understanding local angiotensin II signaling in the bladder, including limitations on clinical translatability. Although there is a strong foundation regarding the local presence and role of angiotensin II signaling in the bladder, further research is needed to support translational applications.
Author List
Anderson HA, Robilotto GL, Mickle ADAuthor
Aaron David Mickle PhD Associate Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Angiotensin IIAnimals
Humans
Muscle Contraction
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Signal Transduction
Urinary Bladder
Urinary Bladder Diseases
