Dynamic sodium chemical shift imaging for the study of aqueous humor flow. Invest Ophthalmol Vis Sci 1991 Jul;32(8):2212-8
Date
07/01/1991Pubmed ID
2071335Scopus ID
2-s2.0-0026014172 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Ocular images were obtained using sodium chemical shift imaging (CSI) and 1,4,7,10-tetraazacyclododecane-N,N'N",N"'-tetramethylenephospho nate thulium (III) [Tm(DOTP)5-], a paramagnetic chemical shift reagent. After injecting the shift reagent into the anterior chamber of rabbits, serial imaging was done, monitoring the change in chemical shift with time. Sodium CSI produced images of the eye in three dimensions, quantitatively depicting the spatial and temporal changes in the concentration of a paramagnetic tracer substance. The Tm(DOTP)5- is eliminated from the anterior chamber by first-order kinetics with a half-life of 49 min. These data suggest that this substance is eliminated from the anterior chamber at the same rate as aqueous humor is replaced. Sodium CSI shows promise as a valuable technique for monitoring fluid dynamics in the living eye.
Author List
Weinberg DV, Kolodny NH, Kohler SJ, Burr TA, Celi A, D'Amico DJ, Gragoudas ESAuthor
David V. Weinberg MD Emeritus Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnterior Chamber
Aqueous Humor
Image Processing, Computer-Assisted
Magnetic Resonance Spectroscopy
Organometallic Compounds
Organophosphorus Compounds
Rabbits
Sodium
