Medical College of Wisconsin
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Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes. Trends Cancer 2024 Nov;10(11):992-1008

Date

09/15/2024

Pubmed ID

39277448

DOI

10.1016/j.trecan.2024.08.005

Scopus ID

2-s2.0-85203805048 (requires institutional sign-in at Scopus site)   23 Citations

Abstract

Emerging evidence indicates that metabolism not only is a source of energy and biomaterials for cell division but also acts as a driver of cancer cell plasticity and treatment resistance. This is because metabolic changes lead to remodeling of chromatin and reprogramming of gene expression patterns, furthering tumor cell phenotypic transitions. Therefore, the crosstalk between metabolism and epigenetics seems to hold immense potential for the discovery of novel therapeutic targets for various aggressive tumors. Here, we highlight recent discoveries supporting the concept that the cooperation between metabolism and epigenetics enables cancer to overcome mounting treatment-induced pressures. We discuss how specific metabolites contribute to cancer cell resilience and provide perspective on how simultaneously targeting these key forces could produce synergistic therapeutic effects to improve treatment outcomes.

Author List

Gantner BN, Palma FR, Pandkar MR, Sakiyama MJ, Arango D, DeNicola GM, Gomes AP, Bonini MG

Author

Benjamin N. Gantner PhD Assistant Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cell Plasticity
Drug Resistance, Neoplasm
Energy Metabolism
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Humans
Neoplasms
Treatment Outcome