Faculty Collaboration Database

An Excised Canine Model of Anterior Glottic Web and Its Acoustic, Aerodynamic, and High-speed Measurements. J Voice 2017 Mar;31(2):246.e21-246.e32

Date

09/28/2016

Pubmed ID

27671751

Pubmed Central ID

PMC5362312

DOI

10.1016/j.jvoice.2016.08.006

Scopus ID

2-s2.0-84995776185 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

OBJECTIVES: This study aims to build an excised anterior glottic web (AGW) model and study the basic voice-related mechanisms of the AGW through investigating the acoustic, aerodynamic, and vibratory properties.

STUDY DESIGN AND METHODS: Overall, four conditions were tested for each of the eight canine larynges used. At baseline, 10%, 20%, and 33% occlusion (as determined by the placement of the suture), acoustic, aerodynamic, and high-speed video data were collected while each larynx was phonated in a soundproof booth.

RESULTS: The phonation threshold pressure (PTP) and the phonation threshold flow significantly increased as percent occlusion increased (P < 0.001). There were significant increases in jitter % and shimmer % from baseline group to AGW model groups at PTP, 1.25 PTP, and 1.5 PTP (P = 0.039, P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P = 0.001, respectively). The fundamental frequency significantly increased as percent occlusion increased at all given pressures (P < 0.001). Correlation dimension (D2) was significantly higher in the AGW model groups than in the baseline group at PTP, 1.25 PTP, and 1.5 PTP (P = 0.002, P < 0.001, P = 0.01, respectively). High-speed videos revealed that, the left phase shift in the AGW model groups compared with the baseline at 1.25 PTP was significant (P = 0.027) and right phase shift at 1.5 PTP (P < 0.001).

CONCLUSIONS: We presented an anatomically similar model of a type 1 AGW and confirmed its validity through aerodynamic, acoustic, and high-speed video analysis in our study. We observed and investigated the glottic web movement, which may be a new explanation for the pathologic voice-related mechanism of AGW.

Author List

Xue C, Pulvermacher A, Calawerts W, Devine E, Jiang J

Author

William Calawerts MD Assistant Professor in the Family Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acoustics
Animals
Biomechanical Phenomena
Congenital Abnormalities
Dogs
Glottis
In Vitro Techniques
Laryngectomy
Larynx
Models, Animal
Phonation
Reproducibility of Results
Suture Techniques
Time Factors
Vibration
Video Recording
Vocalization, Animal