Second trimester inflammatory and metabolic markers in women delivering preterm with and without preeclampsia. J Perinatol 2019 Feb;39(2):314-320
Date
12/07/2018Pubmed ID
30518800Pubmed Central ID
PMC6760589DOI
10.1038/s41372-018-0275-8Scopus ID
2-s2.0-85058059764 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
OBJECTIVE: Inflammatory and metabolic pathways are implicated in preterm birth and preeclampsia. However, studies rarely compare second trimester inflammatory and metabolic markers between women who deliver preterm with and without preeclampsia.
STUDY DESIGN: A sample of 129 women (43 with preeclampsia) with preterm delivery was obtained from an existing population-based birth cohort. Banked second trimester serum samples were assayed for 267 inflammatory and metabolic markers. Backwards-stepwise logistic regression models were used to calculate odds ratios.
RESULTS: Higher 5-α-pregnan-3β,20α-diol disulfate, and lower 1-linoleoylglycerophosphoethanolamine and octadecanedioate, predicted increased odds of preeclampsia.
CONCLUSIONS: Among women with preterm births, those who developed preeclampsia differed with respect metabolic markers. These findings point to potential etiologic underpinnings for preeclampsia as a precursor to preterm birth.
Author List
Ross KM, Baer RJ, Ryckman K, Feuer SK, Bandoli G, Chambers C, Flowers E, Liang L, Oltman S, Dunkel Schetter C, Jelliffe-Pawlowski LAuthor
Liang Liang PhD Assistant Professor in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBiomarkers
Case-Control Studies
Female
Gestational Age
Humans
Infant, Newborn
Logistic Models
Multivariate Analysis
Pre-Eclampsia
Pregnancy
Pregnancy Complications
Pregnancy Trimester, Second
Premature Birth
Risk Factors
Young Adult
