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Maternal dyslipidemia and risk for preterm birth. PLoS One 2018;13(12):e0209579

Date

12/24/2018

Pubmed ID

30576377

Pubmed Central ID

PMC6303099

DOI

10.1371/journal.pone.0209579

Scopus ID

2-s2.0-85058915626 (requires institutional sign-in at Scopus site)   40 Citations

Abstract

Maternal lipid profiles during pregnancy are associated with risk for preterm birth. This study investigates the association between maternal dyslipidemia and subsequent preterm birth among pregnant women in the state of California. Births were identified from California birth certificate and hospital discharge records from 2007-2012 (N = 2,865,987). Preterm birth was defined as <37 weeks completed gestation and dyslipidemia was defined by diagnostic codes. Subtypes of preterm birth were classified as preterm premature rupture of membranes (PPROM), spontaneous labor, and medically indicated, according to birth certificate data and diagnostic codes. The association between dyslipidemia and preterm birth was tested with logistic regression. Models were adjusted for maternal age at delivery, race/ethnicity, hypertension, pre-pregnancy body mass index, insurance type, and education. Maternal dyslipidemia was significantly associated with increased odds of preterm birth (adjusted OR: 1.49, 95%CI: 1.39, 1.59). This finding was consistent across all subtypes of preterm birth, including PPROM (adjusted OR: 1.54, 95%CI: 1.34, 1.76), spontaneous (adjusted OR: 1.51, 95%CI: 1.39, 1.65), and medically indicated (adjusted OR: 1.454, 95%CI: 1.282, 1.649). This study suggests that maternal dyslipidemia is associated with increased risk for all types of preterm birth.

Author List

Smith CJ, Baer RJ, Oltman SP, Breheny PJ, Bao W, Robinson JG, Dagle JM, Liang L, Feuer SK, Chambers CD, Jelliffe-Pawlowski LL, Ryckman KK

Author

Liang Liang PhD Assistant Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Body Mass Index
Dyslipidemias
Female
Fetal Membranes, Premature Rupture
Gestational Age
Humans
Hypertension
Infant, Newborn
Lipids
Logistic Models
Maternal Age
Pregnancy
Pregnancy Complications, Cardiovascular
Premature Birth
Risk Factors