Temporal Dynamics of Oxidative Stress and Inflammation in Bronchopulmonary Dysplasia. Int J Mol Sci 2024 Sep 21;25(18)
Date
09/28/2024Pubmed ID
39337630Pubmed Central ID
PMC11431892DOI
10.3390/ijms251810145Scopus ID
2-s2.0-85205313212 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Bronchopulmonary dysplasia (BPD) is the most common lung complication of prematurity. Despite extensive research, our understanding of its pathophysiology remains limited, as reflected by the stable prevalence of BPD. Prematurity is the primary risk factor for BPD, with oxidative stress (OS) and inflammation playing significant roles and being closely linked to premature birth. Understanding the interplay and temporal relationship between OS and inflammation is crucial for developing new treatments for BPD. Animal studies suggest that OS and inflammation can exacerbate each other. Clinical trials focusing solely on antioxidants or anti-inflammatory therapies have been unsuccessful. In contrast, vitamin A and caffeine, with antioxidant and anti-inflammatory properties, have shown some efficacy, reducing BPD by about 10%. However, more than one-third of very preterm infants still suffer from BPD. New therapeutic agents are needed. A novel tripeptide, N-acetyl-lysyltyrosylcysteine amide (KYC), is a reversible myeloperoxidase inhibitor and a systems pharmacology agent. It reduces BPD severity by inhibiting MPO, enhancing antioxidative proteins, and alleviating endoplasmic reticulum stress and cellular senescence in a hyperoxia rat model. KYC represents a promising new approach to BPD treatment.
Author List
Teng M, Wu TJ, Jing X, Day BW, Pritchard KA Jr, Naylor S, Teng RJAuthors
Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of WisconsinRu-Jeng Teng MD Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsAnti-Inflammatory Agents
Antioxidants
Bronchopulmonary Dysplasia
Humans
Infant, Newborn
Infant, Premature
Inflammation
Oxidative Stress
Rats
