Radiation-Induced Macrovessel/Microvessel Disease. Arterioscler Thromb Vasc Biol 2024 Dec;44(12):2407-2415
Date
10/24/2024Pubmed ID
39445428Pubmed Central ID
PMC11842029DOI
10.1161/ATVBAHA.124.319866Scopus ID
2-s2.0-85207953419 (requires institutional sign-in at Scopus site)Abstract
Radiation therapy (RT) is a cornerstone in cancer treatment (used in 50% of cases), yet challenges persist because damage to normal tissue through direct impact of radiation or bystander effects is inevitable. Injury of macrovessels by RT manifests as obstructive disease, which is akin to atherosclerotic disease. Historically observed in coronary arteries of patients treated for breast cancer and lymphoma, it also affects patients receiving contemporary therapy for lung and chest cancers. Moreover, radiation at various sites can lead to peripheral vascular disease. An aspect of radiation-induced injury that has received little attention is microvascular injury, which typically results from damage to the endothelium and is considered the primary driver of RT-induced toxicity in the skin, kidney, and brain. This review delves into the clinical manifestations of RT-induced vascular disease, signaling pathways, cellular targets affected by radiation injury, and preclinical models of RT-induced vascular injury. The goal is to inspire the development of innovative strategies to prevent RT-related cardiovascular disease.
Author List
Abe JI, Allen BG, Beyer AM, Lewandowski D, Mapuskar KA, Subramanian V, Tamplin MR, Grumbach IMAuthors
Andreas M. Beyer PhD Professor in the Medicine department at Medical College of WisconsinDavid Lewandowski MD Assistant Professor in the Medicine department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsHumans
Microvessels
Neoplasms
Radiation Injuries
Radiotherapy
Risk Factors
Signal Transduction
Vascular Diseases
