Faculty Collaboration Database

Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol. J Perinatol 2025 Mar;45(3):305-311

Date

10/18/2024

Pubmed ID

39420073

Pubmed Central ID

PMC12410120

DOI

10.1038/s41372-024-02141-9

Scopus ID

2-s2.0-85207249232 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

OBJECTIVE: Evaluate the impact of a sodium (Na) supplementation protocol based upon urine Na concentration on growth parameters and morbidities.

STUDY DESIGN: Retrospective cohort study of infants 26^0/7-33^6/7 weeks gestational age (GA) cared for before (2012-15, n = 310) and after (2016-20, n = 382) implementation of the protocol. Within- and between-group changes over time were assessed using repeated measures generalized linear models.

RESULTS: For infants 26^0/7-29^6/7 weeks GA, utilization of the protocol was associated with increased mean body weight z-score at 8-weeks postnatal age, increased mean head circumference z-score at 16-weeks postnatal age, and decreased time on mechanical ventilation (all p < 0.02). No impact on growth was identified for infants 30-33^6/7 weeks GA. Incidences of hypertension, hypernatremia, bronchopulmonary dysplasia, necrotizing enterocolitis, and culture positive sepsis were unaffected by the protocol.

CONCLUSION: Protocolized Na supplementation is associated with improved growth and reduced time on invasive mechanical ventilation in extremely preterm infants without increasing incidence of morbidities.

Author List

Stalter EJ, Verhofste SL, Dagle JM, Steinbach EJ, Ten Eyck P, Wendt L, Segar JL, Harshman LA

Author

Jeffrey L. Segar MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Bronchopulmonary Dysplasia
Clinical Protocols
Dietary Supplements
Female
Gestational Age
Humans
Infant, Extremely Premature
Infant, Newborn
Linear Models
Male
Respiration, Artificial
Retrospective Studies
Sodium