High-salt diet and hypertension: focus on the renin-angiotensin system. Kidney Blood Press Res 2011;34(1):1-11
Date
11/13/2010Pubmed ID
21071956Pubmed Central ID
PMC3214830DOI
10.1159/000320387Scopus ID
2-s2.0-78149355625 (requires institutional sign-in at Scopus site) 129 CitationsAbstract
A high-salt diet is one of the major risk factors in the development and maintenance of hypertension. Numerous experimental and observational studies have confirmed the association of sodium intake with blood pressure levels. The effects of a high-salt diet are related to the function of the renin-angiotensin system, which is normally suppressed by a high-salt diet. Endothelial dysfunction probably plays an important role in the influence of high sodium intake on blood pressure, although the exact mechanisms remain elusive. Genetic factors are known to be very important, and various consomic and congenic rat strains as animal models have proven to be very useful in bringing us a step closer to understanding the interaction between salt intake and hypertension. In this article, experimental data obtained in studies on animals and humans, as well as epidemiological data are reviewed.
Author List
Drenjančević-Perić I, Jelaković B, Lombard JH, Kunert MP, Kibel A, Gros MMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Diet, Sodium-Restricted
Humans
Hypertension
Renin-Angiotensin System
Risk Factors
Sodium, Dietary