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Endophthalmitis from Mycobacterium bovis-bacille Calmette-Guérin after intravesicular bacille Calmette-Guérin injections for bladder carcinoma. Am J Ophthalmol 1999 Nov;128(5):648-50

Date

11/30/1999

Pubmed ID

10577542

DOI

10.1016/s0002-9394(99)00206-8

Scopus ID

2-s2.0-0032731161   21 Citations

Abstract

PURPOSE: To present clinical and histologic findings of intraocular infection with Mycobacterium bovis-bacille Calmette-Guérin after intravesicular bacille Calmette-Guérin injections for treatment of bladder carcinoma.

METHODS: A 77-year-old man was initially seen with visual acuity of 20/200, focal retinitis, vasculitis, and progressive vitreous opacity in the right eye and visual acuity of light perception, intraocular inflammation, and a dense cataract in the left eye 14 months after intravesicular injection of live bacille Calmette-Guérin organisms.

RESULTS: Vitreous cultures in the right eye demonstrated growth of bacille Calmette-Guérin organisms. Bilateral loss of light perception occurred despite systemic antimy-cobacterial therapy. Histopathologic examination demonstrated nongranulomatous inflammation and acid-fast bacilli in both eyes.

CONCLUSION: Delayed endogenous endophthalmitis may develop after intravesicular bacille Calmette-Guérin injection that may not respond to systemic agents. Intravitreal therapy may be indicated.

Author List

Han DP, Simons KB, Tarkanian CN, Moretti ST

Authors

Dennis P. Han MD Adjunct Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin
Kenneth B. Simons MD Sr Associate Dean, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Carcinoma
Endophthalmitis
Eye
Eye Enucleation
Humans
Injections
Male
Mycobacterium Infections
Mycobacterium bovis
Urinary Bladder Neoplasms
Vitreous Body