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Neonatal Outcomes Following Maternal Antepartum Extracorporeal Life Support. ASAIO J 2024 Oct 10

Date

10/13/2024

Pubmed ID

39387840

DOI

10.1097/MAT.0000000000002323

Scopus ID

2-s2.0-85208225958 (requires institutional sign-in at Scopus site)

Abstract

Cases of antepartum respiratory failure or cardiogenic shock treated successfully with extracorporeal life support (ECLS) with high rates of survival for both mother and fetus are well documented. In contrast, there is a paucity of literature on the outcomes of these neonates after delivery. We report a single-center retrospective study of all adult cases of antepartum ECLS from February 2015 to April 2023 with neonatal follow-up. Seven patients met inclusion criteria with a maternal age of 32.0±5.5 years (median ± interquartile range [IQR]), primarily due to respiratory failure in six (86%) patients, with ECLS initiation at 27.0±3.0 weeks gestation. All mothers and fetuses survived to delivery at a gestational age of 29.0±4.5 weeks. All neonates survived to discharge home with the most common comorbidities being prematurity in seven (100%) patients and bronchopulmonary dysplasia in three (43%). In a follow-up period of 1.4±1.2 years; four (57%) patients underwent formal neurodevelopmental testing and two (50%) had identified delays, both related to speech/language. These results suggest that children exposed to antenatal ECLS demonstrate high rates of survival without significant morbidity, but that follow-up for neurodevelopmental delays may be warranted.

Author List

Seadler BD, Johnson A, Donato BB, Andrews WG, Ramamurthi A, Ubert A, Durham LA

Author

Lucian A. Durham MD, PhD Associate Professor in the Surgery department at Medical College of Wisconsin