Tissue plasminogen activator for postvitrectomy fibrin formation. Ophthalmology 1990 Feb;97(2):184-9
Date
02/01/1990Pubmed ID
2109297DOI
10.1016/s0161-6420(90)32618-0Scopus ID
2-s2.0-0025064303 (requires institutional sign-in at Scopus site) 95 CitationsAbstract
The authors injected 25 micrograms of recombinant tissue plasminogen activator (tPA) into the anterior chamber or vitreous cavity of 23 eyes of 22 patients with severe intraocular fibrin formation that developed after vitrectomy surgery for complicated cases of proliferative vitreoretinopathy (PVR) (13 eyes), diabetic traction retinal detachment (TRD) (7 eyes), or endophthalmitis (3 eyes). Tissue plasminogen activator injected an average (+/- standard deviation) of 73 +/- 63 hours after vitrectomy surgery resulted in complete fibrinolysis in 21 of 23 eyes and partial fibrinolysis in one eye. The mean time to fibrin resolution was 3.0 +/- 1.0 hours. Four eyes required repeat tPA injection for recurrent fibrin formation; repeat injection resulted in complete fibrinolysis in each case. The mean follow-up duration after tPA administration was 6 months. At the final follow-up examination, the retina was totally attached in 18 of 23 eyes and was partially attached in 2. Visual acuity improved in 12 eyes (52%); it was at least 20/400 in 8. Complications of tPA injection included hyphema (2 patients) and corneal stromal thickening (2 patients). Mild, transient, periocular pain that was easily managed with non-narcotic analgesia developed in three patients.
Author List
Jaffe GJ, Abrams GW, Williams GA, Han DPAuthor
Dennis Han MD Emeritus Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Anterior Chamber
Child
Endophthalmitis
Female
Fibrin
Follow-Up Studies
Humans
Male
Middle Aged
Pilot Projects
Recombinant Proteins
Retinal Detachment
Retinal Diseases
Tissue Plasminogen Activator
Visual Acuity
Vitrectomy
Vitreous Body
