Leveraging Neural Crest-Derived Tumors to Identify NF1 Cancer Stem Cell Signatures. Cancers (Basel) 2024 Oct 29;16(21)
Date
11/13/2024Pubmed ID
39518076Pubmed Central ID
PMC11545784DOI
10.3390/cancers16213639Scopus ID
2-s2.0-85208430439 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Neurofibromatosis type 1 (NF1) is a genetic disorder that predisposes individuals to develop benign and malignant tumors of the nerve sheath. Understanding the signatures of cancer stem cells (CSCs) for NF1-associated tumors may facilitate the early detection of tumor progression. Background: Neural crest cells, the cell of origin of NF1-associated tumors, can initiate multiple tumor types, including melanoma, neuroblastoma, and schwannoma. CSCs within these tumors have been reported; however, identifying and targeting CSC populations remains a challenge. Results: This study aims to leverage existing studies on neural crest-derived CSCs to explore markers pertinent to NF1 tumorigenesis. By focusing on the molecular and cellular dynamics within these tumors, we summarize CSC signatures in tumor maintenance, progression, and treatment resistance. Conclusion: A review of these signatures in the context of NF1 will provide insights into NF1 tumor biology and pave the way for developing targeted therapies and improving treatment outcomes for NF1 patients.
Author List
Khan S, Alson D, Sun L, Maloney C, Sun DAuthors
Donia Alson Postdoctoral Researcher 2 in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinCaroline Maloney MD, PhD Assistant Professor in the Surgery department at Medical College of Wisconsin
Daochun Sun PhD Assistant Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin
