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The effects of conjugated linoleic acid supplementation on cardiovascular risk factors in patients at risk of cardiovascular disease: A GRADE-assessed systematic review and dose-response meta-analysis. Br J Nutr 2024 Oct 14;132(7):919-934

Date

10/23/2024

Pubmed ID

39439191

DOI

10.1017/S0007114524001065

Scopus ID

2-s2.0-85207933817 (requires institutional sign-in at Scopus site)

Abstract

The present systematic review and meta-analysis sought to evaluate the effects of conjugated linoleic acid (CLA) supplementation on cardiovascular risk factors in patients at risk of CVD. Relevant studies were obtained by searching the PubMed, SCOPUS and Web of Science databases (from inception to January 2023). Weighted mean differences (WMD) and 95% CI were pooled using a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods. A pooled analysis of 14 randomised controlled trials (RCT) with 17 effect sizes revealed that CLA supplementation led to significant reductions in body weight (WMD: -0·72 kg, 95% CI: -1·11, -0·33, P < 0·001), BMI (WMD: -0·22 kg/m2, 95% CI: -0·44, -0·00, P = 0·037) and body fat percentage (BFP) (WMD: -1·32 %, 95% CI: -2·24, -0·40, P = 0·005). However, there was no effect on lipid profile and blood pressure in comparison with the control group. In conclusion, CLA supplementation may yield a small but significant beneficial effect on anthropometric indices in patients at risk of CVD. Moreover, CLA seems not to have adverse effects on lipid profiles and blood pressure in patients at risk of CVD. It should be noted that the favourable effects of CLA supplementation on anthropometric variables were small and may not reach clinical importance.

Author List

Esmaeilnejad M, Rasaei N, Goudarzi K, Behrouz Dehkordi Z, Dolatshahi S, Salehi Omran H, Amirani N, Ashtary-Larky D, Shimi G, Asbaghi O

Author

Hossein Salehi Omran MD Postdoctoral Researcher in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Blood Pressure
Body Mass Index
Body Weight
Cardiovascular Diseases
Dietary Supplements
Dose-Response Relationship, Drug
Female
Humans
Linoleic Acids, Conjugated
Male
Middle Aged
Randomized Controlled Trials as Topic
Risk Factors