Sticky Business: Correlating Oligomeric Features of Class B Scavenger Receptors to Lipid Transport. Curr Atheroscler Rep 2024 Dec 04;27(1):15
Date
12/04/2024Pubmed ID
39630384DOI
10.1007/s11883-024-01260-0Scopus ID
2-s2.0-85211368017 (requires institutional sign-in at Scopus site) 1 CitationAbstract
PURPOSE OF THE REVIEW: Atherosclerotic plaques result from imbalanced lipid metabolism and maladaptive chronic immune responses. Class B scavenger receptors are lipid transporters and regulators of their metabolism. The purpose of this review is to explore recent structural findings of these membrane-associated receptors, with particular focus on their higher-order oligomeric organization and impact on lipid transport.
RECENT FINDINGS: Class B scavenger receptors have evidence for oligomerization, with recent efforts placed on identifying residues and motifs responsible for mediating this process. The first studies correlating scavenger receptor oligomerization to function are described. This review highlights two emerging hypotheses regarding the function of scavenger receptor oligomerization. The first is a hydrophobic channel created by self-association of receptors to promote transport. The second hypothesis suggests that homo-oligomerization stabilizes receptors, prevents internalization and thereby promotes transport indirectly. Novel computational and in vitro experimental techniques with purified receptors are also described.
Author List
Tillison EA, Sahoo DAuthor
Daisy Sahoo PhD Dean, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAtherosclerosis
Biological Transport
Humans
Lipid Metabolism
Scavenger Receptors, Class B
