Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

A method for marker-assisted selection based on QTLs with epistatic effects. Genetica 2003 Sep;119(1):75-86

Date

08/09/2003

Pubmed ID

12903749

DOI

10.1023/a:1024439008631

Scopus ID

2-s2.0-0038717858   24 Citations

Abstract

A method for marker-assisted selection (MAS) based on quantitative trait loci (QTLs) with epistatic effects is proposed. The efficiency of such method is investigated by simulations under a wide range of situations. In the presence of epistasis, MAS generally yields longer persistence response than that based exclusively on additive or additive and dominance. Neglecting epistasis could result in considerable loss in response, and more pronounced at later generations. In addition to population size and trait heritability, genetic variance configurations play an important role in determining both the short- and long-term efficiencies of MAS. MAS using breeding values not only achieves higher response, but also tends to have smaller standard error than other methods in most cases. Errors in QTL detection cause distinct reductions in responses to MAS in most cases. It is thus concluded that verifications of putative QTL and its magnitude of effect and accurate map chromosome location are imperative to realize the potentials of MAS.

Author List

Liu P, Zhu J, Lou X, Lu Y

Author

Pengyuan Liu PhD Adjunct Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Epistasis, Genetic
Genetic Markers
Genetic Variation
Genetics, Population
Models, Genetic
Quantitative Trait Loci
Selection, Genetic
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d