EEG evolution in Sturge-Weber syndrome. Epilepsy Res 2014 May;108(4):816-9
Date
02/25/2014Pubmed ID
24560844Pubmed Central ID
PMC4114141DOI
10.1016/j.eplepsyres.2014.01.023Scopus ID
2-s2.0-84898034546 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
The EEG in Sturge-Weber syndrome (SWS) was theorized over 50 years ago as changing over time from normality to focal asymmetry to lastly epileptiform. We sought to validate these findings in a larger cohort today. Children with confirmed SWS and routine EEG at our center were evaluated retrospectively. An EEG score (0-3) was created and linked to patient current age, overall neurologic function, and seizure frequency. Eighty-one EEGs from 44 patients with SWS (mean age 2.0 years (range: 0.2-37.9 years)) were evaluated and assigned an EEG score. The mean age for patients with an EEG score of 0-1 (normal or focal slowing) was 3.2 years (SEM 0.6), whereas those with an EEG score of 2-3 (focal sharp waves or frequent spike-wave bursts) was 8.7 years (SEM 1.7) (p=0.006). There was no correlation between the EEG score and either the SWS overall neuroscore or seizure subscore (measuring frequency). The EEG in patients with SWS does appear to evolve over time, becoming more abnormal with more frequent epileptiform activity, as suspected in smaller studies decades ago. This progressive change, however, did not correlate with the child's neurologic function or seizure frequency.
Author List
Kossoff EH, Bachur CD, Quain AM, Ewen JB, Comi AMAuthor
Catherine Bachur MD, MA Maternal Fetal Medicine Fellow in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Brain
Child
Child, Preschool
Disease Progression
Electroencephalography
Female
Humans
Infant
Male
Seizures
Sturge-Weber Syndrome
Young Adult