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EEG evolution in Sturge-Weber syndrome. Epilepsy Res 2014 May;108(4):816-9

Date

02/25/2014

Pubmed ID

24560844

Pubmed Central ID

PMC4114141

DOI

10.1016/j.eplepsyres.2014.01.023

Scopus ID

2-s2.0-84898034546 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

The EEG in Sturge-Weber syndrome (SWS) was theorized over 50 years ago as changing over time from normality to focal asymmetry to lastly epileptiform. We sought to validate these findings in a larger cohort today. Children with confirmed SWS and routine EEG at our center were evaluated retrospectively. An EEG score (0-3) was created and linked to patient current age, overall neurologic function, and seizure frequency. Eighty-one EEGs from 44 patients with SWS (mean age 2.0 years (range: 0.2-37.9 years)) were evaluated and assigned an EEG score. The mean age for patients with an EEG score of 0-1 (normal or focal slowing) was 3.2 years (SEM 0.6), whereas those with an EEG score of 2-3 (focal sharp waves or frequent spike-wave bursts) was 8.7 years (SEM 1.7) (p=0.006). There was no correlation between the EEG score and either the SWS overall neuroscore or seizure subscore (measuring frequency). The EEG in patients with SWS does appear to evolve over time, becoming more abnormal with more frequent epileptiform activity, as suspected in smaller studies decades ago. This progressive change, however, did not correlate with the child's neurologic function or seizure frequency.

Author List

Kossoff EH, Bachur CD, Quain AM, Ewen JB, Comi AM

Author

Catherine Bachur MD, MA Maternal Fetal Medicine Fellow in the Obstetrics and Gynecology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Brain
Child
Child, Preschool
Disease Progression
Electroencephalography
Female
Humans
Infant
Male
Seizures
Sturge-Weber Syndrome
Young Adult