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A Roadmap for Implanting Electrode Arrays to Evoke Tactile Sensations Through Intracortical Stimulation. Hum Brain Mapp 2024 Dec 15;45(18):e70118

Date

12/25/2024

Pubmed ID

39720868

Pubmed Central ID

PMC11669040

DOI

10.1002/hbm.70118

Scopus ID

2-s2.0-85213012285 (requires institutional sign-in at Scopus site)

Abstract

Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of a bidirectional brain-computer interface (BCI) to restore upper limb function. Evoking tactile sensations of the hand through ICMS requires precise targeting of implanted electrodes. Here we describe the presurgical imaging procedures used to generate functional maps of the hand area of the somatosensory cortex and subsequent planning that guided the implantation of intracortical microelectrode arrays. In five participants with cervical spinal cord injury, across two study locations, this procedure successfully enabled ICMS-evoked sensations localized to at least the first four digits of the hand. The imaging and planning procedures developed through this clinical trial provide a roadmap for other BCI studies to ensure the successful placement of stimulation electrodes.

Author List

Downey JE, Schone HR, Foldes ST, Greenspon C, Liu F, Verbaarschot C, Biro D, Satzer D, Moon CH, Coffman BA, Youssofzadeh V, Fields D, Hobbs TG, Okorokova E, Tyler-Kabara EC, Warnke PC, Gonzalez-Martinez J, Hatsopoulos NG, Bensmaia SJ, Boninger ML, Gaunt RA, Collinger JL

Author

Vahab Youssofzadeh PhD Assistant Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Brain Mapping
Brain-Computer Interfaces
Electric Stimulation
Electrodes, Implanted
Female
Hand
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Somatosensory Cortex
Spinal Cord Injuries
Touch Perception