The lung HETEs (and EETs) up. Am J Physiol Heart Circ Physiol 2001 Jan;280(1):H1-H10
Date
12/21/2000Pubmed ID
11123211DOI
10.1152/ajpheart.2001.280.1.H1Scopus ID
2-s2.0-0035013924 (requires institutional sign-in at Scopus site) 77 CitationsAbstract
Arachidonic acid metabolites of the cyclooxygenase and lipoxygenase pathways have a variety of important lung functions. Recent observations indicate that cytochrome P-450 (P-450) monooxygenases are also expressed in the lung, localized to specific pulmonary cell types (e.g., epithelium, endothelium, and smooth muscle), and may modulate critical lung functions. This review summarizes recent data on the presence and biological activity of P-450-derived eicosanoids in the pulmonary vasculature and airways, including effects on pulmonary vascular and bronchial smooth muscle tone and airway epithelial ion transport. We hypothesize a number of potential functions of P-450-derived arachidonate metabolites in the lungs such as contribution to hypoxic pulmonary vasoconstriction, regulation of bronchomotor tone, control of the composition of airway lining fluid, and limitation of pulmonary inflammation. Finally, we describe a number of emerging technologies, including congenic and transgenic strains of experimental animals, P-450 isoform-specific inhibitors and inhibitory antibodies, eicosanoid analogs, and vectors for delivery of P-450 cDNAs and antisense oligonucleotides. These tools will facilitate further studies on the contribution of endogenously formed P-450 eicosanoid metabolites to lung function, under both normal and pathological conditions.
Author List
Jacobs ER, Zeldin DCMESH terms used to index this publication - Major topics in bold
8,11,14-Eicosatrienoic AcidAnimals
Cytochrome P-450 CYP4A
Cytochrome P-450 Enzyme System
Humans
Hydroxyeicosatetraenoic Acids
Lung
Microsomes
Mixed Function Oxygenases
Polymorphism, Genetic
Receptors, Cell Surface