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Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. Free Radic Res 1999 Dec;31(6):607-17

Date

01/12/2000

Pubmed ID

10630684

DOI

10.1080/10715769900301181

Scopus ID

2-s2.0-0344146555   27 Citations

Abstract

In this article, we address the mechanism of superoxide formation from constitutive nitric oxide synthases (NOS). Merits and drawbacks of the various superoxide detection assays are reviewed. One of the most viable techniques for measuring superoxide from NOS is electron spin resonance (ESR) spin-trapping using a novel phosphorylated spin trap. Implications of superoxide and peroxynitrite formation from NOS enzymes in cardiovascular and cerebrovascular disorders are discussed.

Author List

Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Tordo P, Pritchard KA Jr, Kalyanaraman B

Authors

Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of Wisconsin
Balaraman Kalyanaraman PhD Chair, Professor in the Biophysics department at Medical College of Wisconsin
Kirkwood A. Pritchard PhD Professor in the Surgery department at Medical College of Wisconsin
Jeannette M. Vasquez-Vivar PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cyclic N-Oxides
Doxorubicin
Electron Spin Resonance Spectroscopy
Humans
Nitric Oxide Synthase
Nitric Oxide Synthase Type II
Oxidation-Reduction
Spin Labels
Superoxides
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a