Interventions to improve β-cell mass and function. Ann Endocrinol (Paris) 2017 Oct;78(5):469-477
Date
09/06/2017Pubmed ID
28870707DOI
10.1016/j.ando.2016.11.002Scopus ID
2-s2.0-85028638214 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Diabetes mellitus (T2DM) has become an epidemiologically important disease worldwide and is also becoming a great matter of concern due to the effects associated with it like: high morbidity, elevated health care cost and shortened life span. T2DM is a chronic metabolic disease characterized by insulin resistance as well as β-cell dysfunction. It is widely accepted that in the face of insulin resistance, euglycemia can be maintained by increase in pancreatic β-cell mass and insulin secretion. This compensation is largely due to enhanced secretion of insulin by the β-cell mass, which is present initially, and thereby subsequent increases in β-cell mass provide additional insulin secretion. However, the mechanism by which β-cell anatomical plasticity and functional plasticity for insulin secretion is coordinated and executed in different physiological and pathophysiological states is complex and has been poorly understood. As the incidence of T2DM continues to increase at an alarming rate, it is becoming imperative to shift the research focus towards the β-cell physiology where identification of novel pathways that influence the β-cell proliferation and/or contribute to increase insulin secretion has the potential to lead to new therapies for preventing or delaying onset of disease.
Author List
Mondal P, Prasad A, Girdhar KAuthor
Khyati Girdhar PhD Assistant Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Proliferation
Diabetes Mellitus, Type 2
Humans
Insulin
Insulin-Secreting Cells
