Audiovisual Synchrony in Left-hemisphere Brain-lesioned Individuals with Aphasia. J Cogn Neurosci 2025 Nov 01;37(11):2190-2202
Date
02/25/2025Pubmed ID
39998896Pubmed Central ID
PMC13435564DOI
10.1162/jocn_a_02316Scopus ID
2-s2.0-105018316257 (requires institutional sign-in at Scopus site)Abstract
We investigated the ability of 40 left-hemisphere brain-lesioned individuals with various diagnoses of aphasia to temporally synchronize the audio of a spoken word to its congruent video using a maximum-likelihood adaptive psychophysical procedure. We found a statistically significant effect of aphasia type, not explained by lesion volume, on measures of audiovisual (AV) synchrony. Brain-lesioned individuals with no symptoms of aphasia, and those with conduction aphasia performed on the synchrony task more similarly to age-matched neurotypical controls, whereas those with anomic aphasia performed the poorest. In addition, we examined the correlation between this ability and AV integration (fusion) and observed a significant correlation between measures of AV synchrony and fusion. An ROI analysis of stroke lesion maps showed that damage to the left posterior temporal regions adversely affected AV processing, although whole-brain univariate lesion-symptom mapping analyses did not yield any significant results. These findings contribute to a better understanding of the functional relationship between different AV processes in multimodal integration and their underlying cortical networks in the human brain.
Author List
Farahbod H, Rogalsky C, Keator LM, Cai J, Pillay SB, LaCroix AN, Fridriksson J, Binder JR, Venezia JH, Saberi K, Hickok GAuthors
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinSara B. Pillay PhD Associate Professor in the Neurology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Acoustic StimulationAdult
Aged
Aphasia
Auditory Perception
Brain
Brain Mapping
Female
Functional Laterality
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Photic Stimulation
Stroke
Visual Perception
