von Willebrand factor mediates platelet adhesion to virally infected endothelial cells. Proc Natl Acad Sci U S A 1993 Jun 01;90(11):5153-6
Date
06/01/1993Pubmed ID
8389471Pubmed Central ID
PMC46673DOI
10.1073/pnas.90.11.5153Scopus ID
2-s2.0-0027265214 (requires institutional sign-in at Scopus site) 68 CitationsAbstract
von Willebrand factor is an adhesive glycoprotein critical to normal hemostasis. It is stored in the Weibel-Palade body of endothelial cells and upon release may mediate platelet adhesion. Herpesvirus-infected endothelium is known to be prothrombotic and to support enhanced platelet adherence. We previously identified P-selectin as a monocyte receptor that is translocated from the Weibel-Palade body to the endothelial cell surface in response to the local generation of thrombin on herpesvirus infected cells. In this study, we show that viral injury to vascular endothelial cells induces secretion of von Willebrand factor which mediates enhanced platelet adhesion to these cells.
Author List
Etingin OR, Silverstein RL, Hajjar DPAuthor
Roy L. Silverstein MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adenoviruses, HumanCell Transformation, Viral
Cells, Cultured
Endothelium, Vascular
Humans
Kinetics
Platelet Adhesiveness
Platelet Membrane Glycoproteins
Simplexvirus
Time Factors
Umbilical Veins
von Willebrand Factor
